Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids.Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.In this work, we investigated the activity of other amidohydrolases on RBM14 compounds.Both bacterial and human purified neutral ceramidases (NCs), as we
This review is an attempt to incorporate water as a structural and thermodynamic component of biomembranes.With this purpose, the consideration of the membrane interphase as a bidimensional hydrated polar head group solution, coupled to the hydrocarbon region allows for the reconciliation of two theories on cells in dispute today: one considering t
The proposed research aims to restore deteriorated text sections that are affected by stain markings, ink seepages and document ageing in ancient document photographs, as these challenges confront document enhancement.A tri-level semi-adaptive thresholding technique is developed in this paper to overcome the issues.The primary focus, however, is on
Summary: Telomerase replicates chromosome ends in germ and somatic stem cells to facilitate their continued proliferation.Telomerase action depends on the telomeric protein TPP1, which recruits telomerase Dog Toys to telomeres and facilitates processive DNA synthesis.Here, we identify separation-of-function long (TPP1-L) and short (TPP1-S) isoforms